Among these factors, the transforming growth factor (TGF)-β family is important in both lineage selection and progression of differentiation of most, if not all, cell and tissue types.

Oncotelic Therapeutics, Inc (OTCQB:OTLC) ("Oncotelic", the "Company" or "We" or “Our”), ”), a leader in RNA-based therapeutics, announced today the successful completion of a Phase 1 clinical trial ...

The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms. Work over the past few years has led to the ...

TGF-β antibody abolished TGF-β1-induced CTGF mRNA expression, but had no effect on SP600125-induced CTGF mRNA expression (Fig. 5). The Smad family of proteins is thought to be the primary ...

Knowing that TGF-Beta was capable of unlocking its receptor while bound by LAP, the UCSF scientists suspected that these proteins might have many more states than just two, which—using typical ...

An enlarging family of matrix-metalloproteinases has ... production and contractility have been attributed to autocrine TGF-beta and endothelin-1, respectively. Stellate cells can amplify the ...