Unlock Mom's Knife by beating Satan with Isaac for a game-changing, penetrating knife. In The Binding of Isaac: Rebirth, players take Isaac on a dangerous journey through his mom's basement.

The Binding Of Isaac has withstood the test of time, but even big fans might find it growing stale. These mods help keep the game fresh. For players looking for a bit of help, Lazarus might be the ...

Check out gameplay and the dangers you'll face in The Last Game in this trailer for the action roguelite bullet hell game inspired by The Binding Of Isaac and Tiny Rogues, where every choice could ...

Edmund McMillen is making a Binding of Isaac card game because he wants to, and it sounds awesome.