This fundamental role in cell life makes topoisomerase I an important target for cancer therapies: its inhibition leads to ...

One of these enzymes is a topoisomerase, which is used by the virus to relieve the excessive twisting of DNA strands that normally occurs during DNA replication and transcription of the viral genes.

More information: John Fielden et al, TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts, Nature Communications (2020). DOI: 10.1038/s41467-020-15000-w Provided ...

and topoisomerase IV (both Type II topoisomerases), which are required for bacterial DNA replication, transcription, repair, and recombination. <18yrs: usually not recommended. See full labeling.

Levofloxacin 5mg/mL; soln for slow IV infusion; preservative-free. Levofloxacin inhibits bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for ...