Kaplan-Lefko P, Chen T, Ittmann M, Barrios R, Ayala G, Huss W, Maddison L, Foster B, and Greenberg N. 2003. Pathobiology of Autochthonous Prostate Cancer in a Pre-clinical Transgenic Mouse Model. The ...

This transgenic model of tauopathy expresses MAPT with the P301S mutation ... and motor impairment. Neuropathologically, these mice exhibit widespread tau pathology, affecting the cerebral cortex, ...

LTP is a model of such use-dependent enhancement ... Figure 2: LTP is impaired in the dentate gyrus in aged APP 695 SWE transgenic mice in vivo. Figure 3: Behavioral deficits in aged APP 695 ...

Our laboratory uses transgenic mice as a model system that can be engineered to reproduce focused aspects of the disease. These models allow us to test cellular and molecular hypotheses about causes ...

tested this hypothesis by treating APP transgenic mice with ibuprofen ... deposition typically begins in this model. The brains of treated and untreated mice were compared 6 months later.

Illustration of Transgenic Mouse Creation: This image shows the process of creating a transgenic mouse. A fertilized egg is held in place by a holding needle while an injection needle introduces ...

Now, in the new study, Sinclair and his colleagues tested whether this relocalization of chromatin modifiers is involved in aging. To do so, they developed a transgenic mouse model carrying a slime ...

Genetically engineered models (mice, rats and zebrafish) are produced by trained professionals at high standards of quality and with excellent efficiency. For the investigator, this approach means ...