Tumor immune evasion mechanisms could be reversed by activating intracellular antiviral immune responses. It has been reported that the use of DNA methyltransferase (DNMT) inhibitors combined with ...

suggesting that SOCS-1 may act as a tumor suppressor. Binding of cytokines to their receptors results in the dimerization of receptor complexes and activation of the Janus family of protein ...

Researchers have discovered how a particular protein affects the growth and spread of colon cancer in humans. The study not ...

However, the real cellular world is laden with oncogenes and tumor suppressor genes whose products interact in overlapping pathways that, when dysfunctional, can lead to cancer. Despite tremendous ...

Two enzyme inhibitors join forces in reducing bladder cancer cell proliferation. n 1996, molecular biologist Kun Ping Lu, a ...

The Dere Lab is actively working on understanding and evaluating the crosstalk between tumor suppressors lost as part of chromosome 3p deletion associated with renal cell carcinoma (RCC). Clear cell ...

When activated, tumor suppressor genes may trigger cells to self-destruct through a process known ... developing the experimental tools that are necessary to study complex and interrelated networks of ...

For example, advanced prostate cancer (PCa) is often linked to changes in the activity of a tumor suppressor ... If we carefully select specific pathways to target that relate to tumor growth ...