Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...

How is a normal cell transformed into a cancerous cell? The proteins involved in cell division events no longer appropriately drive progression from one cell cycle stage to the next. Cells that ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene ... p53 in advanced PDAC increased a-ketoglutarate levels and activated a ...

Northwestern Medicine scientists have uncovered a key pathway controlling tumor growth in B-cell lymphomas, according to a ...

However, the real cellular world is laden with oncogenes and tumor suppressor genes whose products interact in overlapping pathways that, when dysfunctional, can lead to cancer. Despite tremendous ...

A study published in Science Advances reveals a novel strategy that allows tumors to evade the body's immune response ...

A study published in Science Advances reveals a novel strategy that allows tumors to evade the body's immune response critical for their elimination.

Tumor immune evasion mechanisms could be reversed by activating intracellular antiviral immune responses. It has been reported that the use of DNA methyltransferase (DNMT) inhibitors combined with ...

For example, advanced prostate cancer (PCa) is often linked to changes in the activity of a tumor suppressor ... If we carefully select specific pathways to target that relate to tumor growth ...

We found that the myeloid-derived suppressor cells and tumor stem cells literally were in the same place - a region described by pathologists in the 1980s as the pseudopalisading region.