Downstream of the pre-BCR, SYK (spleen tyrosine kinase) has a central role in the ... the activation of IgL gene recombination. Pre-BCR signalling through PI3K–PKB inhibits IgL gene ...
Although tyrosine kinase inhibitors (TKIs ... be involved in stemness regulation and ERK1/2 to have a key role in the signaling pathway. TKIs unexpectedly promoted stemness marker expression ...
Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...
In 1987 I attended a meeting at Cold Spring Harbor on phosphatidylinositol signaling that turned out to be pivotal for me. A few years earlier I'd helped show that a phosphatidylinositol (PI) kinase ...
Investigators conducted a retrospective review that spanned 10 years with the goals of describing the clinical ...
The following is a summary of “Post-transplant TKIs for Ph+ ALL: practices to date and clinical significance,” published in ...
Chemotherapeutic agents are often used to treat cancer. They combat tumor growth, but also have a number of undesirable side ...
Sorafenib is an oral tyrosine kinase inhibitor able to inhibit VEGF receptors 1, 2 and 3, PDGF receptors α and β, RET, Flt3, c-KIT and the RAF kinase and MAPK pathways. Over 10,000 patients have ...
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