We believe that the ubiquitin/proteasome pathway is involved in so many cellular processes that it could not be properly described by a single model substrate and that the minimal requirement ...

The proteasome is a large protein complex in the cytoplasm of eukaryotic and archaeal cells responsible for proteolysis of proteins that have one or more poly-ubiquitin post-translational ...

They report in Cell this week that the system involves a ubiquitin-protein ligase that specifically targets four distinct mutant nuclear proteins for destruction by the proteasome. Protein quality ...

Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to ...

In this way, the researchers found that the proteasome is effectively clogged up, accelerating cell death. At the same time, ...

Their compounds activate 20S proteasomes, which can identify and degrade disordered proteins without the need for ubiquitin ...