A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart -- an important process for maintaining heart health.

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart – an important process for maintaining heart health.

The physiological roles of DUBs are as pervasive as the ubiquitin–proteasome system itself. Here we use selected examples to illustrate broad functional categorization. USP44 deubiquitylates ...

Cells maintain a continuous free pool of ubiquitin that can be conjugated onto target proteins to mark them for degradation by the proteasome. Now, in Cell, Finley and colleagues show that the ...

New research uncovers how declining protein clearance mechanisms with age lead to Alzheimer’s, Parkinson’s, and other ...

Degradation: Damaged proteins are broken down via the ubiquitin-proteasome system or lysosomes. ・Aggregate clearance: Autophagy eliminates clusters of misfolded proteins. These systems degrade ...

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...

Edited by: Thomas W. Durso and Karen Young Kreeger M. Hochstrasser, "Ubiquitin, proteasomes, and the regulation of intracellular protein degradation," Current Opinion in Cell Biology, 7:215-23, 1995. ...

Their compounds activate 20S proteasomes, which can identify and degrade disordered proteins without the need for ubiquitin ...

Our team is focused on study the function of Ubiquitin Proteasome System (UPS) components in Arabidopsis growth and development as well as in responses to environmental challenges. Our team is also in ...