are certainly of interest but do not yet provide an informative tool useful in the screening of inhibitors ... steps (ubiquitin tagging, unfolding, and proteolysis) of the ubiquitin/proteasome ...

The clinical success in hematological malignancies of bortezomib has bolstered interest in the development of a new generation of proteasome inhibitors, varying in their mode of action through ...

There are also ubiquitin-like proteins such as NEDD8, ISG15 or SUMO that act as homologous pathways for ubiquitination. Bortezomib was the first-in-class proteasome inhibitor and is currently ...

In March 1 Journal of Clinical Investigation Thomas Zollner and colleagues from JW Goethe University of Frankfurt, Germany, show that proteasome inhibition reduces superantigen-mediated T cell ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...