The clinical success in hematological malignancies of bortezomib has bolstered interest in the development of a new generation of proteasome inhibitors, varying in their mode of action through ...

are certainly of interest but do not yet provide an informative tool useful in the screening of inhibitors ... steps (ubiquitin tagging, unfolding, and proteolysis) of the ubiquitin/proteasome ...

In March 1 Journal of Clinical Investigation Thomas Zollner and colleagues from JW Goethe University of Frankfurt, Germany, show that proteasome inhibition reduces superantigen-mediated T cell ...

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart -- an important process for maintaining heart health.

Pyrimidine compounds acting as ubiquitin carboxyl-terminal hydrolase 1 (USP1) inhibitors and reported to be useful for the treatment of cancer have been disclosed in a recent Asieris Pharmaceuticals ...

Exelixis Inc. has synthesized fused pyrazole derivatives acting as ubiquitin carboxyl-terminal hydrolase 1 (USP1) inhibitors reported to be useful for the treatment of cancer.

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart – an important process for maintaining heart health.

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

There are also ubiquitin-like proteins such as NEDD8, ISG15 or SUMO that act as homologous pathways for ubiquitination. Bortezomib was the first-in-class proteasome inhibitor and is currently ...