They treated human PC3 prostate cancer cells with antisense phosphorothioate oligonucleotides (PS-ODNs) or with 2'-O-methyl RNA/DNA hybrid ODNs and examined changes in the expression profiles of over ...

However, whether the drug can truly be called "antisense" depends on some specifics--such as the ability to bind to targeted messenger RNA (mRNA) but avoid clinging to other proteins. Representatives ...

Scientists recently studied how different factors affect antisense oligonucleotides (ASOs) under hydrophilic interaction ...

The earlier deal gave Sanofi a stake in Resalis Therapeutics, an Italian biotech that is advancing an antisense oligonucleotide that targets a noncoding RNA involved in obesity pathways.

which is designed to overcome limitations in existing antisense technologies by targeting RNA-level intracellular disease mechanisms. Alloy claims the platform improves a drug’s therapeutic ...

The FDA has granted fast-track designation to an investigational antisense oligonucleotide to treat individuals with myotonic ...