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PLoS Pathogens|张继明教授团队和谢幼华教授团队揭示MSX1抑制乙肝病毒 ...
团队前期研究表明,MSX1可通过直接结合增强子II/核心启动子(EnII/Cp)并抑制其启动子和增强子活性来抑制HBV的基因表达和复制。除了上述调控机制外,MSX1还在转录后水平下调HBx蛋白的稳定性,且不受HBX基因型的影响。进一步证实,MSX1通 ...
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