"The effort of producing high-resolution cryo-EM images is wasted if they are compromised by poor sample preparation," Usukura says. He advises that a good sample for cryo-EM is, most importantly ...

Cryo-EM reveals how Wnt, a key signal molecule for human development and cancer, is modified by an enzyme named PORCN. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news ...

Moreover, data collection at low temperature reduces sample damage by the electron beam, improving the resolution of the EM images. This paper thus marks the early development of cryo-EM.

Every day, billions of cells in your body divide, helping to replace old and injured cells with new ones. And each time this ...

What is Cryo-Electron Microscopy? Cryo-electron microscopy (cryo-EM) is a powerful technique used to determine the three-dimensional structure of biological macromolecules, such as proteins and ...

The replication of the Nipah virus's genetic material in infected cells has been demonstrated for the first time by ...

Scientists at Sanford Burnham Prebys and the Mayo Clinic used cryogenic electron microscopy to create 3D images detailing the overall structure of ubiquitous mitochondrial creatine kinase.

By freezing molecules at temperatures around minus 196 C (about minus 320 F) and bombarding them with streams of electrons, cryo-EM produces images that can show the molecules' three-dimensional ...

The University of Colorado Boulder Biochemistry Department's Krios Electron Microscopy facility (BioKEM) offers single particle cryo-EM and cryo tomography of plunge-frozen samples. The BioKEM ...