Epidermal growth factor receptor (EGFR) is expressed in 50% of ... responders harboured specific mutations in the gene that encodes EGFR. Exon 19 mutations characterized by in-frame deletions ...

The IPASS (Iressa Pan-Asia Study) is the first large randomized clinical trial that compared first-line EGFR TKI therapy with chemotherapy. 1 In this study, 1,217 Asian non-smokers or former light ...

EGF receptor (EGFR ... Mechanisms of EGFR upregulation are dependent on the cancer type (i.e., kinase domain mutations in lung cancer, amplification in brain tumors and breast cancer ...

“While we’re not yet at the point where we ... epidermal growth factor receptor (EGFR), a protein that helps cells grow and divide. In NSCLC cells with the EGFR mutation, the signal is always ...

Interestingly, cancers that co-overexpress EGFR and HER2 have a worse clinical outcome than those overexpressing either receptor alone ... type (i.e., kinase domain mutations in lung cancer ...

Using microarrays to perform a genome-wide assessment of the receptor network, they found that EGFR and ErbB2 bind to proteins more promiscuously, and activate many more signaling pathways, as they ...