siRNA能抑制特定致癌基因表达，展现出较好的抗肿瘤潜力。然而其临床应用面临多重障碍，如负电荷亲水性阻碍细胞摄取，溶酶体逃逸能力不足导致 ...

The following is a summary of "Clinicopathologic and genomic analyses of SMARCA4-mutated non-small cell lung carcinoma ...

2025年2月19日，中国科学院生物物理研究所范克龙和阎锡蕴团队在《Science Advances》期刊上发表题为"Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in ...

New RNA-based active agents reliably protect plants against the Cucumber mosaic virus (CMV), the most common virus in ...

Silexion Therapeutics Corp. has completed its initial study evaluating SIL-204 in orthotopic pancreatic cancer models. SIL-204 is a next-generation siRNA candidate designed to target a broad range of ...

The Core maintains a repository of over 50 constructs containing CFTR and other relevant mutations, together with gene editing and other molecular tools ... Ribosomal profiling is also offered.