In hepatocytes, ferroptosis faces physiological constraints due to the liver's multilayered antioxidant systems. These include ferritin-mediated iron sequestration, GPx4 activity, and high levels ...
SF >1000 µg/l is associated with a substantial risk of cirrhosis and therefore a liver biopsy is recommended for staging. C282Y homozygous patients with normal or mildly elevated ferritin can ...