The product of this tumor suppressor gene, a 105-kilodalton polypeptide called pRB, `is a cell cycle regulator. The pRB polypeptide inhibits cell proliferation by arresting cells at the G1 phase of ...

The released E2F promotes the transcription of target genes involved in cell cycle progression. The pRB/E2F signaling pathway is controlled by DNA methyltransferase-1 (Dnmt-1). The elevated ...

factors involved in maintenance of cell cycle checkpoints, and proteins required for apoptosis induction. The types of genetic alterations leading to pRb inactivity most often involve frameshifts ...

Both the retinoblastoma gene product (pRB) and cyclin A, two of the adenovirus E1A targeted cellular proteins, have been shown to play critical roles in cell-cycle regulation in several labs. p33cdk2 ...