通过对TP53研究的延展和借鉴，研究人员有望在更广泛的癌症基因研究中找到新的突破口。这项研究标志着癌症基因研究从单一突变分析向系统性 ...

TP53 loss progressively increases CNAs and structural variants, which followed by appearance of aneuploidy and loss/gain of ...

Study examines the effect of TP53 mutations on outcomes in MDS patients receiving haploidentical haematopoietic stem cell ...

In many cancer types, the TP53 gene is often mutated or deleted, which inactivates the tumour suppression activity of the p53 protein. However, loss of p53 tumour-suppressor activity can also ...

Within a cohort they examined, they found, first, that the subtype itself has two subtypes; and then, in one of those, called low hypodiploid ALL, 91 percent of patients carried certain variants of ...

PhD Defense of W.P.J. Cox (UMC Utrecht/Kinderen) ...

A study released by the National Cancer Center Japan has revealed higher rates of mutations in a tumor-suppressing gene, TP53, in Japanese cancer patients compared to those in the United States ...