The question of putative mechanisms of action continues to haunt psychopharmacology. Put simply, we know these drugs work, but we have very little idea how. We make guesses based on the ...

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Their protective effects are at least partly mediated by direct activation of the AhR pathway, as well as indirect effect through AhR-IL-22 axis activation. IEC are involved in the mechanisms of ...

Canonically, the metabolic depletion of tryptophan and/or the accumulation of kynurenine is the mechanism that defines how immunosuppressive IDO inhibits immune cell effector functions and/or ...

The mechanism of action underlying ketamine’s rapid antidepressant effects in patients with depression, both suffering from major depressive disorder (MDD) and bipolar disorder (BD), including ...

Target validation is the process by which the predicted molecular target – for example protein or nucleic acid – of a small molecule is verified. Target validation can include: determining the ...

American Healthcare REIT, Inc. (the "Company") (NYSE: AHR) announced today that members of its board of directors and management team will ring The Opening Bell® at the New York Stock Exchange on ...

Copy number variants (CNVs) arise by homologous recombination (HR) between repeated sequences (recurrent CNVs) or by non-homologous recombination mechanisms that occur throughout the genome (non ...

Even though there are indications of the health-promoting and cell-protective properties of ergothioneine, the underlying mechanism of action was previously unknown. "Our analyses now finally ...

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