SLC25A1 drives citrate export from the mitochondria to the cytosol, where it fuels acetyl-CoA synthesis by ATP citrate lyase (ACLY). This acetyl-CoA supply sustains FSP1 acetylation and prevents its ...

This review focuses on intergenerational and transgenerational epigenetic inheritance in different plants, animal species and ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

Drugs targeting amyloid plaques have failed to show efficacy in clinical trials. A new approach is needed to tackle AD ...

A study published in the Journal of Neuroscience sheds new light on how brain cells relay critical information from their ...

In a groundbreaking study led by Dr. Ying Chen and her team from Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, researchers have uncovered a novel mechanism behind endothelial ...

Histone post-translational modifications are covalent modifications of histones by phosphorylation on serine or threonine residues, methylation on lysine or arginine, acetylation and deacetylation ...

Organ transplantation is often heralded as a miraculous medical advancement, offering individuals with failing organs a second chance at life. However, alongside the physical and medical challenges of ...

Beyond acetylation, short-chain lysine acylations like propionylation (Kpr) and butyrylation (Kbu) link metabolism to gene regulation via acyl-coenzyme A. (acyl-CoA) availability. Read the full ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

Researchers uncover a link between genetic mutations and epigenetic changes, two major contributors to aging. Their findings reveal that mutations trigger cascading epigenetic alterations, suggesting ...