Conversely, we next generated FBXW7 fat-conditional knockout mice (FBXW7-FKO mice) by crossing FBXW7-LoxP mice with Adiponectin-Cre mice (Appendix Fig. S6A). We confirmed efficient and specific ...

The control mice were fed a regular chow diet (NCD mice, n=10, A5002,13.5% Kcal from fat, Shanghai Slac Laboratory Animal Co. Ltd). A total of 20 mice were fed on HFD (# D12492, 60% Kcal from fat, ...

For the first time, however, experts succeeded in visually tracking the movement of microplastics through brain blood vessels in mice—and the pile-ups resembled a microscopic “car crash.” ...

Dave's been wielding mice in anger since the hoary ol' days of the Amiga 500, Deluxe Paint, and Dune 2. He even plugged one into his Commodore 64 once, but he got over that. He's had his paws on ...

Having the best gaming mouse for your library at your disposal means more than having the fastest sensor or the most buttons under your thumbs. These rodents come in all shapes and sizes these ...

The best gaming mouse can transform how it feels to interact with your favorite games. With a top rodent, every click or swipe takes you closer to winning in the best PC games, but a poor mouse ...

The best computer mouse isn't necessarily the one with the most buttons, the flashiest lights or the lightest weight. Depending on what you're doing at the computer, the kind of mouse that you'll ...

In this study, we identify an E3 ubiquitin ligase, tripartite motif-containing protein 32 (TRIM32), as a key regulator of hepatic insulin signaling that targets the insulin receptor (INSR) for ...