1). Although this may be the result of a greater sensitivity of aldosterone biosynthesis to the inhibitory effects of amphenone, it may also be due to the known differences in the homeostatic ...

Inherited defects in aldosterone biosynthesis thus cause hypovolemia, hyponatremia and hyperkalemia. Defective aldosterone biosynthesis may be caused by congenital adrenal hyperplasia due to 21 ...

Aldosterone synthase inhibition is an emerging area of research with significant therapeutic potential, particularly in the treatment of conditions associated with elevated aldosterone levels ...

Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart ...