The management of Leishmania donova ni (LD), responsible for fatal visceral leishmaniasis (VL), faces increasing challenges due to rising drug-unresponsiveness, leading to increasing treatment ...

Because of the toxicities associated with amphotericin B deoxycholate, many patients at our institution are switched to a lipid formulation of amphotericin B once an increase in serum creatinine ...

Nephrotoxicity, the major complication of long-term therapy with amphotericin B, is attributed to drug-induced renal vasoconstriction plus a direct toxic action on renal tubules. Hypokalemia and ...

Expert Rev Anti Infect Ther. 2013;11(7):709-721. Adverse effects of amphotericin B deoxycholate appear to be less common in neonates than in older children and adults. Reported adverse effects ...

They are composed of a lipid ... liposomal formulations of drugs like doxorubicin (such as Doxil®) enhance drug accumulation in tumor tissues through the enhanced permeability and retention (EPR) ...

B vitamins (also known as vitamin B complex) are a group of eight essential nutrients that support nearly all of your body’s functions, including metabolism, energy production, brain and nervous ...

Institute of Pharmaceutical Sciences, University of Freiburg, Freiburg 79104, Germany ...

LNPs typically consist of four fundamental components: ionizable lipids, polyethylene glycol (PEG)-lipids, phospholipids, and sterols (as shown in Figure 1A,B). This formulation has been successfully ...

(NYSE American: MTNB) announces that negotiations under the previously disclosed non-binding term sheet regarding global rights to MAT2203, its oral formulation of amphotericin B, have been ...

CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is also the target of ...

Purpose: Age-related eye diseases are becoming more prevalent. A notable increase has been seen in the most common causes including glaucoma, age-related macular degeneration (AMD), and cataract.

This study provides useful insights into the ways in which germinal center B cell metabolism, particularly lipid metabolism, affects cellular responses. The authors use sophisticated mouse models to ...