In the following section, the various methods used to evaluate antihistamines illustrate the developmental process for evaluating the efficacy of the H 1-receptor antagonist desloratadine.

For the antihistamine desloratadine, in vitro studies have revealed it to be a highly potent H 1-receptor antagonist and inhibitor of inflammatory mediators. Animal models with desloratadine have ...

An antihistamine is a type of medication that is used to relieve or prevent allergy symptoms such as runny nose, sneezing, and watery eyes. Antihistamines work by blocking histamine — a chemical ...

Initial screening assays were performed with a large number of typical and atypical antipsychotic drugs. In preliminary studies, we discovered that selected typical and atypical antipsychotic ...

Many antihistamines can cause drowsiness. It’s not recommended to take them for sleep, as little research backs up their effectiveness. Long-term use may also lead to harmful side effects.

In the ASTERIA I and ASTERIA II trials, omalizumab demonstrated significant efficacy for patients aged 12 to 75 years who remained symptomatic despite optimized H1 antihistamine therapy. Patients ...

Newer antihistamines cause less drowsiness than older ones. Which one should you pick when hay fever or other allergies strike?

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1942—Antergan becomes the first antihistamine tested in humans and goes on the market. 1972—James Black discovers the H2 receptor and characterizes its antagonist, burimamide. 1999 ...

Broadly speaking, the potential side effects are minimal. “Puberty blockers are typically administered via intramuscular injection or a surgical implant,” explains Osipoff. As with any ...

Over time, levels of the hormones testosterone and estrogen can become imbalanced in males, potentially causing health problems. Medications called estrogen blockers are among the treatment options ...