The mechanisms accounting for the aberrant accumulation of fibroblasts during fibrotic repair are poorly understood, although evidence supports a role for fibroblast resistance to apoptosis as a ...

This lack of suppression was not only caused by impaired Treg function but was also due to B cell resistance to regulation. In healthy donors, control by Treg was associated with increased B cell ...

After treating a tumor with chemotherapy and radiotherapy, cells known as senescent cells can appear. These are cells that do ...

This study aimed to develop curcumin-loaded maltodextrin-based proniosomes (CMPNs) and to evaluate their therapeutic efficacy against gemcitabine-resistant CCA both in vitro and in vivo. We focused on ...

The study is based on the analysis of human senescent cells in a specific tumor model — melanoma, which affects skin cells known as melanocytes — and, more specifically, melanocytes exposed to ...

Research reveals IGFBP6's role in suppressing vascular inflammation and atherosclerosis, suggesting it as a novel target for ...

Programmed cell death (apoptosis) seems to be the principal mechanism whereby anti-oncogenic therapies such as chemotherapy and radiation effect their responses. Resistance to apoptosis ...

Figure 1. A, PAH pathology. Immunohistochemistry in human samples from a patient with iPAH; staining with an antibody against smooth muscle actin is shown. Note the excessive cell proliferation in ...

Selective modulation of the apoptotic machinery has been the goal of oncology developers for more than two decades. The field continues to face special challenges. Many of the targets are ...

Dual blocking SHP2 and FGFR2 can not only promote the targeted tumor-killing effects and overcome FGFR2 inhibitor resistance caused by feedback activation, but also activate T cell-mediated anti-tumor ...

Background Cystic fibrosis (CF) lung disease is defined by large numbers of neutrophils and associated damaging products in the airway. Delayed neutrophil apoptosis is described in CF although it is ...