The reward for unlocking the mysteries of DNA repair could be significant. For instance, women with defective versions of the BRCA repair proteins have a much higher risk of aggressive breast and ...

His team discovered that, when functioning properly, BRCA2 helps to repair a specific kind of DNA damage called double-strand breaks. Without it, cells make imperfect repairs, introducing the ...

Homologous recombination plays essential roles in the repair ... stranded DNA with the filament (green and brown), while the other is sequestered away (red). The non-homologous part of the DNA is ...

Under this two-hit model, Brugge says, one normal copy of BRCA1 ought to be able to carry out DNA repair even when the other copy is inactivated by an inherited mutation. This means that a total ...

Because DNA replication errors or environmental agents that damage DNA can introduce mutations if not corrected, multiple cellular DNA repair mechanisms ... end resection in BRCA-deficient ...

“The surprising result of our research is that DNA repair, which normally protects healthy cells ... The team also found that ...

Advances in DNA sequencing technologies in the 1990s allowed a team working in the US to identify the BRCA1 gene by sequencing DNA from families with high rates of breast cancer and identifying ...

But, new research has discovered a method to isolate those dangerous mutations, thereby finding a way to fix them. When BRCA1 ...

That's because she has a gene mutation called BRCA1, which affects around one in every 300-400 people. This is her story in her own words. Hayley Minn Hayley's grandmother died of breast cancer ...

How do tumor cells die after radiotherapy- one of the most important type of cancer treatment- is one of the big mystery in ...

A study reveals that the way cancer cells die after radiotherapy depends on DNA repair methods. By blocking specific repair ...

and BRCA2 (BReast CAncer gene 2) are genes that produce proteins that help repair damaged DNA. Everyone has two copies of each of these genes-one copy inherited from each parent. "Mutations ...