to repair DNA damage, in men with BRCA1 genetic variants, say the researchers. A linked editorial suggests that the findings pave the way for greater refinement of genetic testing and personalized ...

Of the many types of DNA damage that exist within the cell, probably the most dangerous is the DSB. These result from exogenous agents such as ionizing radiation (IR) and certain chemotherapeutic ...

Right now, women with BRCA1 alterations can opt for watchful ... through a constellation of genes that monitor cells for DNA damage, repair DNA breaks or, when all else fails, tell defective ...

The double ring, spool-like structure of RAD52 protects replicating DNA in dividing cells. A study led by the University of ...

Steven A. (Tony) Leadon resigned as director of radiobiology at the University of North Carolina at Chapel Hill (UNC) in March, after a five-member panel at the school alleged that he had tampered ...

such as those with defects in BRCA1 and BRCA2 genes.” Cancers with DNA repair deficiencies depend on other proteins to ...

such as those with defects in BRCA1 and BRCA2 genes.” Cancers with DNA repair deficiencies depend on other proteins to provide backup pathways for DNA repair, which allows the cancer cells to ...

Cancers with DNA repair deficiencies depend on other proteins to provide backup pathways for DNA repair, which allows the cancer cells to proliferate fast and survive despite DNA damage.