Cell death is a crucial biological process that can occur through various mechanisms, including apoptosis, which is a form of programmed cell death. Bax inhibitor proteins, particularly those ...

Figure 1. miMOMP activates mtDNA-cGAS-STING pathway and promotes cellular senescence and tissue aging. ABT-737 promoted BAX activation and formation of BAX/BAK macropore, thus induced miMOMP and mtDNA ...

Various PD-1 and PD-L1 checkpoint inhibitors have been approved by U.S. regulators including blockbuster drugs Keytruda, Imfinzi, and Opdivo to treat different types of cancer. But that hasn’t stopped ...

It is the second drug in the PD-1/PD-L1 inhibitor class to be cleared in a subcutaneous injection form by the FDA after Roche's Tecentriq Hybreza (atezolizumab and hyaluronidase) – which got a ...

Introduction: To design effective small molecule inhibitors targeting the immune checkpoint PD-1/PD-L1 and to explore their inhibitory activity. Methods: In this paper, a total of 69 PD-1/PD-L1 ...

We sell different types of products and services to both investment professionals and individual investors. These products and services are usually sold through license agreements or subscriptions ...

GLP-1 inhibitors such as semaglutide and tirzepatide have become popular and effective for weight loss and blood sugar control. However, they’re not without side effects. Keep in mind the following to ...

Tyrosine (Tyr) phosphorylation of p27 by Abl and Src family kinases reduces p27–CDK2 inhibition and transforms p27 from inhibitor to substrate ... Figure 1: Schematic model of p27 levels and ...