Our perspective about glucose toxicity as it pertains to the pancreatic ß-cell is that the characteristic decreases in insulin synthesis and secretion are caused by decreased insulin gene expression.

Cells, known as beta-cells, in the pancreas produce and store insulin, a hormone that keeps glucose levels in blood ... past the cell wall (membrane), to interact with, and influence the ...

Thousands of glucose molecules can be linked together to form the complex carbohydrate cellulose. Cellulose is a very tough molecule that is used to build the cell wall of plant cells. Plant cells ...

For example, beta cells secrete insulin in response to increased blood glucose levels, and this stimulates cells to take up glucose, an essential step in energy homeostasis. In contrast ...