One of Spider-Man's most notorious villains will mark his return in a ... become Massacre was injured by shrapnel that fixed to his brain, leaving him wholly devoid of emotion.

Spider-Man's villains are incredibly iconic ... During one of the LIzard's mutations, his reptilian brain completely took ...

The resulting chaos kills Otto's wife, welds the metal arms to his spine, and fries the chip, which rewires his brain ... Unlike many of Spider-Man's great villains, Otto Octavius dies a hero.

then no one would remember the bubble-headed villain or anything he ever said. No memory of Mysterio, no common public memory that Peter Parker is Spider-Man. Bam, problem solved. It's even a ...

Spider-Man 4 will reportedly introduce a female main villain, sparking fan theories and speculation. Potential villains include Black Cat, Silver Sable, and Spider-Queen with intricate connections ...