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CD44v6—— 胃癌治疗的新希望:调控癌症干细胞的关键靶点
CD44v6 调节 CSC 标记物表达并维持胃癌 CSC 特性:在 MKN-45 和 NCI-N87 细胞系中进行实验,结果显示,敲低 CD44v6 后,关键 CSC 标记物 CD44、CD24、CD133 和 EpCAM 的表达均下降,维持干细胞自我更新和多能性的关键转录因子 Oct-4 和 Nanog 的 mRNA 水平也显著降低;而 CD44v6 过 ...
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