CD44v6 调节 CSC 标记物表达并维持胃癌 CSC 特性：在 MKN-45 和 NCI-N87 细胞系中进行实验，结果显示，敲低 CD44v6 后，关键 CSC 标记物 CD44、CD24、CD133 和 EpCAM 的表达均下降，维持干细胞自我更新和多能性的关键转录因子 Oct-4 和 Nanog 的 mRNA 水平也显著降低；而 CD44v6 过 ...

To investigate the mechanisms of solid tumor heterogeneity, we developed a modification of the NOD/SCID mouse model in which human breast cancers were efficiently propagated in the mouse mammary fat ...

Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice developed obesity.

在肿瘤细胞侵袭性研究中，分化程度被视为预后的关键指标。病理学家发现，低分化肿瘤细胞保持着胚胎发育早期的增殖特性，其端粒酶活性是正常细胞的5-8倍。这类细胞不仅失去接触抑制特性，更通过MMP-2/9金属蛋白酶大量分泌，每小时可溶解3.2μm基底膜。这种生物学特性导致低分化肿瘤术后2年复发率高达47.6%，显著高于中高分化肿瘤的21.3%。分子生物学研究揭示，Wnt/β-catenin信号通路异常激活 ...

Purpose: Given the higher precision accompanied by optimized sparing of normal tissue, charged particle therapy was thought of as a promising treatment for pancreatic cancer. However, systematic ...

UPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, Pennsylvania 15232, United States Department of Computational and Systems Biology, University of Pittsburgh, 3420 ...

SENP1 represses the SUMOylation of HIF-1α at K391 and K477 by its SENPs activity, which decreases the stability and transcriptional activity of HIF-1α, thus increasing the expression of HIF target ...

Interleukin-27 (IL-27) is a member of the IL-12 family. The gene encoding IL-27 is located at chromosome 16p11. IL-27 is considered as a heterodimeric cytokine, which consists of Epstein–Barr virus ...