such as E-cadherin (Fig. 1). Through a distinct binding site, β-catenin also binds to the unrelated protein α-catenin, which in turn binds to filamentous actin. Thus, β-catenin provides the ...

A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell. The work, published Jan. 29 in Nature Communications, reveals a new signaling mechanism ...

It has not been clear, though, exactly how the antibodies attach to P-cadherin or how they get inside the cancer cell once attached. Bin Xie and Shipeng Xu, graduate students in biophysics and ...

Understanding the binding targets for antibodies against cadherin could help design drugs that exploit this pathway to find and destroy cancer cells. The work was supported in part by a grant from ...

Understanding the binding targets for antibodies against cadherin could help design drugs that exploit this pathway to find and destroy cancer cells.

OnCusp Therapeutics receives US FDA fast track designation for CUSP06 for treatment of platinum-resistant ovarian cancer: Princeton, New Jersey Saturday, February 15, 2025, 15:00 ...