A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell. The work, published Jan. 29 in Nature Communications, reveals a new signaling mechanism ...

Understanding the binding targets for antibodies against cadherin could help design drugs that exploit this pathway to find and destroy cancer cells. The work was supported in part by a grant from ...

such as E-cadherin (Fig. 1). Through a distinct binding site, β-catenin also binds to the unrelated protein α-catenin, which in turn binds to filamentous actin. Thus, β-catenin provides the ...