Medscape2 天
Promise for CAR T-Cell Therapies in Solid Tumors?
CAR T-cell therapies have demonstrated efficacy in treating blood cancers but, so far, their safety and effectiveness in ...
The Scientist9 天
Inducible CAR T Cells Target Solid Tumors Better
Researchers at Cellectis leveraged gene editing to create a CAR T cell that acts in an IF/THEN system. Traditional methods to develop CAR T cells that use the patient’s cells introduce challenges ...
Science Daily1 天
Gene modification could improve cancer treatment's success rate
A research team has made a major discovery on how the CUL5 gene affects CAR-T cell therapy, an advanced cancer therapy. The study reveals that reducing the activity of the CUL5 gene helps CAR-T cells ...
Frontiers4 天
Advancements in Solid Tumor Immunotherapy: Enhancing Efficacy and Overcoming Resistance
In oncology, immunotherapy stands as a transformative approach for treating solid tumors, notably through pioneering treatments like immune checkpoint ...
Too Old to Operate10 天
A Review of CAR T Cells and Adoptive T-Cell Therapies in Lymphoid and Solid Organ Malignancies.
The results from ongoing studies and clinical trials are awaited in solid tumors (melanoma, sarcomas, and carcinomas). This article reviews recent developments and ongoing challenges in adoptive ...
Medical Xpress10 天
CAR-T cells can arm bystander T cells with CAR molecules in tumor microenvironment
CAR-T cells can transfer CAR molecules to other T cells in the tumor microenvironment through trogocytosis, a process where immune cells exchange surface molecules.