ImmuneOnco Biopharmaceuticals has shown Chinese biotechs are far from immune to the pressures to prioritize pipelines. | ...

Magrolimab has been at the forefront of drugs targeting CD47, a protein expressed on cancer cells that sends out a ‘don’t eat me’ signal to macrophage cells of the immune system, and was the ...

The researchers looked at stem cells from AML patients at the Stanford Medical Center to see if they also expressed CD47. “They all did,” says Weissman. After demonstrating in cell culture experiments ...

Figure 2: Formation of a phagocytic synapse between an apoptotic cell and a macrophage. But what is different about CD47 on apoptotic cells? One obvious possibility is that CD47 is downregulated ...

Targeting SIRP-alpha primes macrophages to attack and destroy cancer ... that is governed by the interaction of SIRP-alpha and CD47, another big research area in cancer immunotherapy.