non-HDL cholesterol (HDL-C) is a secondary target of therapy after the LDL-C goal has been achieved. Non-HDL-C concentration is highly correlated, but may be discordant with that of ApoB.

Scientists have discovered a potential new treatment for familial hypercholesterolemia, inspired by signs seen in the Mona ...

Atherogenic lipoprotein particles can vary considerably in their cholesterol content, but each particle contains only one molecule of apoB-100 (or simply apoB). As a result, serum concentration of ...

As they deliver triglyceride to tissues, the particles shrink to 18–30 nm, transitioning into LDL with cholesterol as the dominant lipid. Structural changes in apoB-100 enhance its binding to ...

Jan. 29, 2025 — Older adults whose cholesterol changes over time may be more likely to develop dementia than people whose cholesterol is stable, regardless of the actual cholesterol level ...

Low-density lipoproteins (LDL) - commonly known as bad cholesterol - have long been on scientists' radar as a major contributor to heart disease. But these microscopic troublemakers have hidden their ...

High cholesterol levels lead to plaque formation in arteries that restrict blood and oxygen flow. Familial ...

This condition arises from mutations in specific genes responsible for cholesterol regulation, such as the LDLR, APOB, and PCSK9 genes. These mutations impair the body's ability to remove LDL ...

Methods Total cholesterol, non-high-density lipoprotein cholesterol (non-HDL-c), low-density lipoprotein cholesterol (LDL-c), HDL-c, triglycerides, apolipoprotein B (ApoB) and apolipoprotein A1 (ApoA1 ...