Scleroderma is classified as a rare, autoimmune, collagen-vascular disease of unknown etiology that can be difficult to diagnose and treat. Its onset can be insidious or rapid; the symptoms range ...

Early intervention to enhance these mitochondrial processes could potentially slow disease progression. Atherosclerosis and other vascular inflammatory ... and type III collagen and results ...

Scleroderma is an autoimmune connective-tissue disease whose ... abnormal vascular endothelium, and an exaggerated production of fibroblasts that results in abnormal collagen buildup (see Figure).