By exploring candidates for synthetic lethality, we unexpectedly uncover that KDM1A promotes survival after DAC treatment through interactions with ZMYM3 and CoREST, independent of its demethylase ...

此前研究虽发现 UM171 可诱导赖氨酸特异性组蛋白去甲基化酶 1a（LSD1）和 CoREST 降解，但直接靶点和作用机制依旧成谜，这也成为研究人员开启此次探索之旅的重要契机。 研究方法：多技术协同破难题 蛋白质组学分析：研究人员在 SET - 2 和 MV4;11 两种对 UM171 敏感 ...

为了深入研究这些机制，该研究使用了深度突变扫描技术来描绘KBTBD4突变热点的突变景观，并曝光了隐含的功能获取机制对不同类型突变的偏好，再结合冷冻电子显微镜对KBTBD4癌变体与LSD1–HDAC1–CoREST复合物的结构分析，揭示了癌症突变如何通过改变蛋白质表面 ...

Tranylcypromine is an inhibitor of lysine-specific demethylase 1 (LSD1), which converts H3K4me2 to H3K4me1 or H3K4me0 by removing a chromatin mark associated with open chromatin used in neuronal ...

Bacteria have developed many strategies to defend themselves from phages — the viruses that infect them. The Zorya defence system uses a previously undescribed antiviral strategy. An inner ...

Copyright 2025 The Associated Press. All Rights Reserved. Washington Redskins’s John Riggins (44) heads for the end zone for the team’s second touchdown in the ...

2025 年 2 月 12 日，国际顶尖学术期刊 Nature 上线了 29 篇论文，其中 14 篇来自华人学者（包括作为通讯作者和第一作者的论文）。 2 月 12 日，西湖大学柴继杰教授作为通讯作者，在 Nature 期刊发表了题为：Balanced plant helper NLR activation by a modified host protein complex（一 ...