Cyclic nucleotide signaling plays a crucial role in the regulation of heart function, particularly in the context of heart failure (HF). Cyclic adenosine monophosphate (cAMP) and cyclic guanosine ...

cAMP signaling is known to influence different cellular processes, including apoptosis, migration, and DNA repair mechanisms, which are critical in cancer progression and treatment responses. The ...

Cyclic adenosine monophosphate (cAMP) is a crucial second messenger in cellular signaling pathways, playing a significant role in various physiological processes, including metabolism, cell growth ...

Alfa Chemistry has made a remarkable stride in the field of synthetic biology with the recent renewal of its oligonucleotide series products. This updated lineup includes a range of advanced ...

A mutation in the S1 helix of the cyclic nucleotide-gated channel (CNGC ... DMI1 and CNGC15GOF was shown to fine-tune calcium signaling, promoting efficient symbiotic responses.

the Mitochondrial Antiviral Signaling (MAVS) protein and its role in anti-viral innate immunity, and more recently, cyclic GMP-AMP synthase (cGAS) and a new cyclic di-nucleotide signaling pathway that ...

TLRs critically link innate immunity to adaptive immunity by regulating the activation of antigen-presenting cells and key cytokines. Furthermore, recent studies also have shown that TLR signaling can ...

Earl W. Sutherland Jr., former professor and chair of the Department of Pharmacology, led the discovery of cyclic AMP, a cellular signaling molecule responsible for many metabolic processes. He won ...

Department of Chemistry, University of California, Berkeley, California 94720, United States ...

Recognition of nucleic acids by DNA sensors induces IFN-I and interferon-stimulated genes (ISGs), but the involvement of cyclic guanosine monophosphate (GMP)–AMP synthase (cGAS) and stimulator of ...