siRNA能抑制特定致癌基因表达，展现出较好的抗肿瘤潜力。然而其临床应用面临多重障碍，如负电荷亲水性阻碍细胞摄取，溶酶体逃逸能力不足导致 ...

阳光诺和与安龙生物正式达成项目与战略合作，共同推进小核酸siRNA技术平台在心脑血管治疗领域的应用，研发一款该领域的小核酸（siRNA）创新药物。

Reporting in Nature, Kumar and colleagues have now developed a method to target small-interfering RNA (siRNA) to the CNS, providing a safe and non-invasive approach for the delivery of this new ...

In Type 2 diabetes, Junevity’s first siRNA therapeutic candidate improved glucose control and insulin sensitivity in diabetic mice without causing weight gain or other side effects associated ...

highlighted by its blockbuster diabetes drug Mounjaro (tirzepatide) which pulled in $5.2bn global sales in 2023, as per Lilly ...