Thus, we studied in vitro platelets - OPCs interactions. Consistent with these observations, we noticed that a short exposure (pulse) to platelets boosted OPC differentiation and the generation of ...

However, the mechanisms regulating this synchronization and its long-term functional implications remain poorly understood. Here, we unveil a novel role for oligodendrocytes in orchestrating ...

Stem-cell differentiation is the process by which a more specialised cell is formed from a stem cell, leading to loss of some of the stem cell's developmental potential. Stem-cell differentiation ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. This study presents convincing findings that oligodendrocytes ...

After injury, ependymal cells displayed minimal activation and demonstrated no significant proliferation or cross-lineage differentiation. Importantly, the study revealed that the reactivity of ...

In healthy people, this damage can be repaired by oligodendrocytes ... of remyelination as a potentially first-in-class and differentiated therapy for RRMS patients. In a mouse model of MS ...

Explore the role of preclinical MRI in studying neurological diseases, with a focus on advanced cellular and molecular ...

Oligodendrocytes have been shown to be involved in the regulation of glutamate ... (LA); lactate dehydrogenase (LDH); monocarboxylate transporter (MCT); mechanistic target of rapamycin (mTOR); myeloid ...

After staining, sections were rinsed in 95% EtOH and distilled water. Differentiation was carried out by immersing the sections in Lithium Carbonate solution (0.05%; Sigma Aldrich, catalog # L-3876) ...

Widespread tau-positive glial inclusions, tufted astrocytes and coiled bodies in oligodendrocytes are seen. Immunohistochemistry and staining with tau antibodies that recognize each of the six ...