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CHD8-TRRAP 轴在人类神经干细胞中调控 MYC 和 E2F 靶基因的关键作用
其发病与遗传因素密切相关,而 Chromodomain helicase DNA-binding protein 8(CHD8)基因突变是导致自闭症的重要单基因 ... 进一步分析发现,它们常常在含有 MYC 和 E2F 结合位点的启动子以及 MYC 和 E2F 靶基因的启动子上共定位。这意味着它们可能在这些基因的调控中发挥 ...
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