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Moreover, higher levels of dipeptidyl peptidase 4 (DPP-4) in patients with obesity may additionally impair the immune system, with inhibition of DDP-4 improving insulin sensitivity in both obese and ...

Upon ICOS-L binding, it enhances FoxP3 transcription which, in turn, increases IL-4, TGF-β, and IL-10 secretion. ICOS+ Treg normally co-express co-inhibitory surface molecules important for their ...

Cardiac fibrosis is common in patients with severe aortic stenosis and an independent predictor of death. Therefore, we examined the additional value of circulating fibrosis markers as a putative ...

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