Epigenetic inhibitors as a promising new antimalarial intervention strategy? A new study identifies an inhibitor of gene regulation that specifically ...

Thanks to the growing field of epigenetics, we're learning more about the interplay of genetic inheritance and environment in ...

The most common HDAC inhibitors include phenylbutyric acid, SAHA, depsipeptide, and valproic acid (Egger et al., 2004). Caution in using epigenetic therapy is necessary because epigenetic ...

Oral, once-daily doses of VYN202 being evaluated in subjects with moderate-to-severe plaque psoriasisTop-line data from the 12-week double-blind ...

The parasite that causes malaria requires precise control of gene expression to progress through the various stages of its ...

Figure 2 Combining epigenetic drugs with immune checkpoint inhibitors. Persistent antigen stimulation and inflammatory factors in chronic inflammation can cause dysfunction of tumor-infiltrating T ...

Targeting chromatin dysregulation in PDAC can overcome cell plasticity and primary or secondary therapeutic resistance A hitherto underestimated vulnerability towards inhibitors of chromatin ...

In this article, published data in support of the notion that endometriosis is an epigenetic disease are reviewed. The desirable properties of histone deacetylase inhibitors as therapeutics for ...

Another critical and complex factor to consider in the administration of HDAC inhibitors is the metabolic state of the host; since epigenetic and metabolic changes in cancer cells are interrelated ...

Oral, once-daily doses of VYN202 being evaluated in subjects with moderate-to-severe plaque psoriasis Top-line data from the 12-week double-blind trial expected by year-end 2025 Phase 1b trial designe ...