Methods: Here, we assess the efficacy of clinically usable CAR-engineered NK cell line NK-92/5.28.z against ErbB2-positive RMS in vitro and in a metastatic xenograft ... by a quantitative real-time ...

Gene regulation refers to the mechanisms that act to induce or repress the expression of a gene. These include structural and chemical changes to the genetic material, binding of proteins to ...

PFS, chemo 1 st line gem-based vs. 5FU-based 4.2 vs. 4.1 m (p=0.70) 2 nd line gem-based vs. 5FU-based 3.0 vs 3.2 m (p=0.89) ...

This complex process, known as gene expression, determines which proteins ... the AI system that predicts the three-dimensional structure of proteins. The transformative technology was recognized ...

Jan. 30, 2025 — A research group has developed new advanced light-controlled tools that enable precise control of proteins in real time in living cells. This groundbreaking research opens doors ...

The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

Genomic Characterization and Prognostic Significance of Human Epidermal Growth Factor Receptor 2–Low, Hormone Receptor–Positive, Early Breast Cancers From the BIG 1-98 and SOFT Clinical Trials ...

Unlike full-length ENO1, MBP-1 is a mainly nuclear protein acting as a transcriptional repressor that regulates the expression of oncogenes, including c-Myc, COX2, and ERBB2. (12−17) ENO1 is also ...

The first human trial of insulin-producing cells that have been gene-edited to evade immune attack is a success so far. The cells have survived and produced insulin for a month after being ...

A ba­by boy born with a de­bil­i­tat­ing ge­net­ic dis­ease will like­ly no longer re­quire a liv­er trans­plant to sta­bi­lize his con­di­tion, thanks to a first … ...