The relatively low signal-to-noise ratio prevalent in expression technology ... which not only estimates fold-changes, but also assigns a statistical significance to the change through a P ...

Ageing of the brain leads to impairments in cognitive and motor skills, and is the major risk factor for several common neurological disorders such as Alzheimer disease (AD) and Parkinson disease ...

while a downregulated gene produces less. Comparing chimpanzees and humans to macaques enabled the researchers to tell when differences between the two apes were due to changes in chimpanzees, changes ...

The scientists speculate that this might allow gene expression patterns to undergo rapid changes. It may also help the cells ...

The analysis showed a broad range of expression changes among these DEGs, with some exhibiting up to 550-fold differences compared to the wild type. Gene Ontology (GO) analysis of up-regulated ...