In contrast, ACAT2-deficient mice fed the HF/HC diet had HMGR-expression ... not shown), which contains cholic acid, an inhibitor of genes encoding cholesterol 7α-hydroxylase.

In two new papers, researchers from The Jackson Laboratory (JAX) report the successful use of two approaches—gene therapy and ...

A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) on December 12, 2024, Volume 16, Issue 22, titled “Arginase-II gene ...

Researchers have identified a method to enhance the effectiveness of a promising cancer treatment. They found that modifying ...

Gene expression related to fertilization, sperm motility, and sperm structure in the testes of Tle6-deficient mice showed an overall increase. Together, the findings of this study highlighted the ...

Our work has several limitations due to the technical difficulties: (1) we were unable to specifically knock out the Nlrp3 gene in pericytes and analyze the distinct pathogenic effect of NLRP3 in ...

Gene expression related to fertilization, sperm motility, and sperm structure in the testes of Tle6-deficient mice showed an overall increase. Together, the findings of this study highlighted the ...

The study found that Ccr4 deficiency led to qualitative changes in atherosclerotic plaques, characterized by an increased inflammatory phenotype. The authors further analyzed the CD4 T cell immune ...

Researchers have identified a unique mitochondrial process in CA2 neurons that supports learning, memory, and social recognition.