Tumor cells altered metabolism by increasing glucose uptake and fermentation of glucose to lactate ... Glucose-derived citrate is converted to acetyl-CoA, oxaloacetate (OAA), or a-ketoglutarate (a-KG) ...

Macrophages exist in most tissues of the body, where they perform various functions at the same time equilibrating with other cells to maintain immune responses in numerous diseases including cancer.

Oct. 7, 2024 — Researchers discovered combining the brain-penetrating antipsychotic drug pimozide with a clinically investigative glutamine metabolism inhibitor, CB-839, can overcome tumor ...

Being a Cantonese Singaporean, Traditional Chinese Medicine (TCM) has always been in my life (and the world’s for the past ...

We suggest that shared genetic risk factors for the development of cancer and cognitive problems, including low-efficiency efflux pumps, deficits in DNA-repair mechanisms and/or a deregulated ...

But despite its primary role to prevent pregnancy, the contraceptive pill (or 'the Pill') could also help reduce the risk of ovarian cancer, according to new ... Inhibitor Drugs to Treat ...

9 Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China Objective Metastasis is the major cause of cancer death. However, what types of heterogenous cancer cells ...

Preclinical MRI, Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal Neuroengineering and Computational Neuroscience, Institute for Research and Innovation in Health (i3S), Porto, ...

Objective The extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is still unclear. However, several Trp metabolism ...